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Rituximab's Role in Minimal Change Disease and Focal Segmental Glomerulosclerosis with Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome in Adults

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Emedinexus    06 May 2024

IntroductionRituximab is an effective and safe treatment for pediatric patients with frequently relapsing or steroid-dependent nephrotic syndrome (FR/SDNS). AimThe present study analyzed the efficacy and safety of Rituximab in adult FR/SDNS patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS).Methods:This retrospective study examined relapse frequency and first relapse-free survival time. It also recorded adverse events. Results:The study prescribed an average rituximab dose of 1,393.8 ± 618.7 mg/2 years to 81 patients during the 2-year follow-up period. It observed a significant decrease in relapse frequency after rituximab treatment. The first relapse-free survival time was 16.7 ± 8.0 months. 70.4% achieved cessation of corticosteroids and immunosuppressants within three months following the first rituximab infusion.Adverse events were mostly mild, and no severe treatment-related adverse events occurred. Low serum albumin levels before Rituximab and high CD56+CD16+ natural killer cell count remained independent risk factors of relapse within two years after Rituximab treatment.ConclusionThis study proves Rituximab is an effective and safe treatment option for adult FR/SDNS patients with MCD or FSGS in maintaining disease remission and minimizing corticosteroid exposure.

Reference-

Lan L, Lin Y, Yu B, et al. Efficacy of Rituximab for Minimal Change Disease and Focal Segmental Glomerulosclerosis with Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome in Adults: A Chinese Multicenter Retrospective Study. Am J Nephrol. 2024;55 (1): 25–36.

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