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Increased Cardiac Risks Linked to Antipsychotic Drugs Quetiapine and Haloperidol

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Emedinexus    01 November 2024

A recent study published in the journal Heart Rhythm has revealed a concerning association between the use of antipsychotic drugs, quetiapine, and haloperidol, and an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) stemming from drug-induced heart rhythm disorders.


The research, emphasizing the need for caution, urges healthcare professionals to manage cardiac risks diligently when prescribing these medications. Cardiac concerns related to antipsychotic use have been a focal point for the past three decades, leading to the removal or restriction of certain drugs from the market due to their elevated risk of lethal ventricular arrhythmias.


The researchers conducted a retrospective analysis of electronic medical records from a substantial patient cohort in Taiwan who underwent quetiapine or haloperidol therapy. Investigators examined the incidences, risk factors, and clinical correlates of severe QT prolongation, a condition linked to ventricular arrhythmias and sudden cardiac death.


The significant findings underscored that over 10% of patients developed severe QT prolongation during the follow-up period. The study highlighted an elevated risk of ventricular arrhythmias and sudden cardiac death, specifically in users of quetiapine or haloperidol who experienced severe QT prolongation.

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