A study finds that combining daylight photodynamic therapy with LED illumination significantly reduces actinic keratosis in solid organ transplant recipients compared to daylight therapy alone. This combination treatment offers enhanced effectiveness for high-risk patients.

A study published in JDDG: Journal der Deutschen Dermatologischen Gesellschaft explored the treatment of actinic keratosis (AK) in solid organ transplant recipients, who are at an increased risk due to immunosuppressive therapy. The study aimed to compare the effectiveness of combining daylight photodynamic therapy (d-PDT) with LED illumination against d-PDT alone.

The study was conducted at the University of Navarra Clinic and included 13 patients with 169 AK lesions. After both treatment areas received d-PDT, one was randomized to receive additional LED illumination. The primary endpoint was the reduction of AK lesions 12 weeks post-treatment.

The results showed a significant improvement in the area treated with d-PDT and LED illumination, achieving a 79.55% reduction in AK lesions compared to 65.43% in the area treated with d-PDT alone (p < 0.05).

The findings suggested that combining LED illumination with daylight photodynamic therapy enhances the effectiveness of treating actinic keratosis in solid organ transplant recipients. This approach could provide a more effective treatment option for patients at high risk of developing skin lesions.

(Source:https://www.dermatologytimes.com/view/immunocompromised-patients-with-actinic-keratosis-respond-well-to-led-daylight-photodynamic-combination-therapy )