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eMediNexus 17 October 2018
The aim of a study published in the Anales de Pediatria was to assess the renal safety of treatment with polyethylene glycol (PEG) with electrolytes at 1, 3 and 6 months, its gastrointestinal tolerance and dose effectiveness. This study recruited three groups comprising 30 children each, in the age-range of 2-10 years, who suffered from functional constipation diagnosed according to the Rome III criteria. PEG 3350 with electrolytes was administered to these patients, treatment was evaluated at 1, 3 and 6 months. Efficacy was evaluated by the change in the number of stools per week and stool consistency (Bristol scale). Urine screens, sodium and osmolality, were performed at the beginning and after 1, 3 and 6 months of treatment. PEG 3350 dosage ranged from 0.18-0.8g/kg/day. Significant improvements were observed in the number of stools per week after the treatment compared to the baseline. The Bristol scale score also recorded a marked difference in outcomes indicating improvements in the stool consistency. Meanwhile, the mean sodium intake was 112mg. The values of sodium and urine osmolality were normal in all groups with no statistical difference compared to normal control values. Furthermore, NIRA values were normal in all patients and hydrogen breath test was normal with a median of 7ppm. Thus, this therapy displayed optimal tolerance and efficacy. Hence, it was concluded that polyethylene glycol 3350 with electrolytes can be safely recommended for the treatment of functional constipation in children in the short and long term.
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